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  • Imai, M.; Uchiyama, J.; Takemura-Uchiyama, I.; Matsuzaki, S.; Niko, Y.; Hadano, S.; Watanabe, S.* "Highly Specific and Sensitive Detection of Bacteria by Dark-Field Light-Scattering Imaging based on Bacteriophage-modified Magnetoplasmonic Nanoparticles" Bull. Chem. Soc. Jpn., 97 (2), 1–9 (2024).

  • Nishihara, H.; Watanabe, M.; Kawakami, R.; Murakami, M.; Seki, H.; Osaki, K.; Tsuda, T.; Imamura, T.; Hadano, S. Watanabe, S.; Niko, Y.* "Pyrene-Fused Dioxaborine-Based Merocyanines with High Brightness, Photostability, and Fluorogenic Function for Deep-Skin Tissue Imaging of a Living Mouse" Bull. Chem. Soc. Jpn., 97 (3), 1–7 (2024).


  • Liu, F.; Anton, N.; Niko, Y.; Klymchenko, A. S.* "Controlled Release and Capture of Aldehydes by Dynamic Imine Chemistry in Nanoemulsions: From Delivery to Detoxification" ACS Appl. Bio Mater.  6, 246–256 (2023).

  • Murakami, M.*; Kawakami, R.; Niko, Y.; Tsuda, T.; Imamura, T. "A new fluorescent three-dimensional and deep-imaging technique for histological identification of individual tumor cells in extramammary Paget's disease" Exp. Dermatol., 32, 712–714 (2023).

  • Sekida, S.; Chisaka, T.; Uchiyama, J.; Takemura-Uchiyama, I.; Matsuzaki, S.; Niko, Y.; Hadano, S.; Watanabe, S.* "Bacteriophage-Conjugated Fluorescent Nanoemulsion as a Novel Optical Probe for HighlySelective Bacterial Detection" Bull. Chem. Soc. Jpn., 96, 1234–1242 (2023).

  • Oya, S.; Korogi, K.; Kohno, T.; Tsuiji, H.; Danylchuk, D. I.; Klymchenko, A. S.; Niko, Y.; Hattori, M.* "The Plasma Membrane Polarity Is Higher in the Neuronal Growth Cone than in the Cell Body of Hippocampal and Cerebellar Granule Neurons" Biol. Pharm. Bull., 46, 1820–1825 (2023).


  • Kaneko, M.; Nakayama, T.; Seki, H.; Yamamoto, S.; Uemura, T.; Inoue, K.; Hadano, S.; Watanabe, S.; Niko, Y.* "Lipophilic Nitrile N-Oxide for Catalyst-Free Surface Modification of Nanoemulsions as Light-Harvesting Nanoantennas" Bull. Chem. Soc. Jpn.  95, 1760–1768 (2022), selected paper.

  • Tsutsumi, N.; Ito, A.; Niko, Y.; Bando, Y.; Takahashi, K.; Ikeda, M.; Yoneyama, K.; Nakamura, T.; Izumi, M.; Ochi, R.* "Glycolipid‐Type Amphiphiles with a Small Anilinochloromaleimide‐Based Luminogen Exhibiting Aggregation‐Induced Emission" ChemistrySelect , 7 (2022).

  • Matsuura, H.; Kawakami, R.; Isoe, M.; Hoshihara, M.; Minami, Y.; Yatsuzuka, K.; Tsuda, T.; Murakami, M.; Suzuki, Y.; Kawamata, J.; Imamura, T.; Hadano, S.; Watanabe, S.; Niko, Y.* "NIR-II-Excitable Dye-Loaded Nanoemulsions for Two-Photon Microscopy Imaging of Capillary Blood Vessels in the Entire Hippocampal CA1 Region of Living Mice" ACS Appl. Mater. Interfaces., 4 , 40481–40490 (2022).​

  • Inoue, K.;  Kawakami, R.; Murakami, M.; Nakayama, T.; Yamamoto, S.; Inoue, K.; Tsuda, T.; Sayama, K.; Imamura, T.; Kaneno, D.; Hadano, S.; Watanabe, S.; Niko, Y.* "Synthesis and photophysical properties of a new push–pull pyrene dye with green-to-far-red emission and its application to human cellular and skin tissue imaging" J. Mater. Chem. B, 10, 1641–1649 (2022).

  • Mori, W.; Kawakami, R.; Niko, Y.; Haruta, T.; Imamura, T.; Shiraki, K.; Zako, T.* "Differences in Interaction Lead to the Formation of Different Types of Insulin Amyloid" Sci. Rep., 12, 1–15 (2022).


  • Niko, Y. ; Watanabe, S. (2021) “Fluorescent Chemosensors” in Ooyama, Y. & Yagi, S (Eds) Progress in the Science of Fuctional Dyes, Springer Singapore, Chapter 12, pp.377–408. (Book)

  • Niko, Y.*; Klymchenko, A.S. "Emerging solvatochromic push–pull dyes for monitoring the lipid order of biomembranes in live cells" J. Biochem., 0(0) 1–12 (2021).

  • Murakami, M.*; Kawakami, R.; Niko, Y.; Tsuda, T.; Yatsuzuka, K.; Mori, H.; Imamura, T.; Sayama, K. "New fluorescent three-dimensional and deep-imaging technique confirms a direct relationship between the acrosyringium and vesicles/pustules of palmoplantar pustulosis" J. Dermatol. Sci. (2021).

  • Takezaki, M.; Kawakami, R.; Onishi, S.; Suzuki, Y.; Kawamata, J.; Imamura, T.; Hadano, S.; Watanabe, S.; Niko, Y.* “Integrated Fluorescent Nanoprobe Design for High-Speed In Vivo Two-Photon Microscopic Imaging of Deep-Brain Vasculature in Mice” Adv. Funct. Mater. 2010698 (2021), selected as an inside front cover.

  • Liu, F.; ※Niko, Y.; Bouchaala, R.; Mercier, L.; Lefebvre, O.; Andreiuk, B.; Vandamme, T.; Goetz, J.G.; Anton, N.; Klymchenko, A.S.* “Drug‐Sponge Lipid Nanocarrier for in Situ Cargo Loading and Release Using Dynamic Covalent Chemistry” Angew. Chem. Int. Ed., 60, 2–10 (2021).(※筆頭著者との equal contribution)

  • Murakami, M.*; Kawakami, R.; Niko, Y.; Tsuda, T.; Mori, H.; Yatsuzuka, K.; Imamura, T.; Sayama, K. “High-quality Fluorescence Imaging of the Human Acrosyringium Using a Transparency: Enhancing Technique and an Improved, Fluorescent Solvatochromic Pyrene Probe” Acta Histochem. Cytochem., 53, 131–138 (2020).

  • Sot, J.; Esnal, I.; Monasterio, B. G.; León-Irra, R.; Niko, Y.; Goñi, F. M.; Klymchenko, A. S.; Alonso, A.*, “Phase-selective staining of model and cell membranes, lipid droplets and lipoproteins with fluorescent solvatochromic pyrene probes” BBA. Biomembranes, 1863, 183470 (2021).


  • Valanciunaite, J.; Kempf, E.; Seki, H.; Danylchuk, D. I.; Peyriéras, N.; Niko, Y.*; Klymchenko, A. S.*, “Polarity mapping of cells and embryos by improved fluorescent solvatochromic pyrene probe” Anal. Chem., 92, 6512-6520 (2020).

  • Saito, A.; Yamamoto, S.; Ochi, R.; Inoue, K.; Hadano, S.; Watanabe, S.; Nakayama, T.*; Niko, Y.*, “An Azide-Tethered Cremophor® ELP Surfactant Allowing Facile Post-Surface Functionalization of Nanoemulsions” Bull. Chem. Soc. Jpn., 93, 568-575 (2020), selected as a BCSJ Award Article and a front cover.



  • Imai, M.; Mine, K.; Tomonari, H.; Uchiyama, J.; Matuzaki, S.; Niko, Y.; Hadano, S.; Watanabe, S.*, “Dark-Field Microscopic Detection of Bacteria using Bacteriophage-Immobilized SiO2@AuNP Core–Shell Nanoparticles” Anal. Chem., 91, 12352-12357 (2019).


  • Seki, H.; Onishi, S.; Asamura, N.; Suzuki, Y.; Kawamata, J.; Kaneno, D.; Hadano, S.; Watanabe, S.; Niko, Y.*, “Bright and Two-Photon Active Red Fluorescent Dyes that Selectively Move Back and Forth between the Mitochondria and Nucleus upon Changing the Mitochondrial Membrane Potential” J. Mater. Chem. B, 6, 7396-7401 (2018), selected as an outside back cover.

  • Sekida, S.; Kameyama, T.; Koga, T.: Hadano, S.; Watanabe, S.; Niko, Y*, “Highly-lipophilic and solid emissive N-annulated perylene bisimide synthesis for facile preparation of bright and far-red excimer fluorescent nano-emulsions with large Stokes shift” J. Photochem. Photobiol A, 364, 16-21 (2018).


Faculty of Science and Technology, Kochi University




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